Mitochondrial DNA abnormalities in ophthalmological disease
نویسندگان
چکیده
منابع مشابه
Mitochondrial abnormalities in Alzheimer's disease.
The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is primarily limited to the cytoplasm of susceptible neuronal populations suggests that mitochondrial abnormalities might be part of the spectrum of chronic oxidative stress of Alzheimer's disease. In this study, we used in situ hybridization to mitochondrial DNA (mtDNA), immunocytochemistry of cytochrome...
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OBJECTIVES To further characterize mtDNA defects associated with autistic features, especially the A3243G mtDNA mutation and mtDNA depletion.Study design Five patients with autistic spectrum disorders and family histories of mitochondrial DNA diseases were studied. We performed mtDNA analysis in all patients and magnetic resonance spectroscopy in three. RESULTS Three patients manifested isola...
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ژورنال
عنوان ژورنال: Saudi Journal of Ophthalmology
سال: 2011
ISSN: 1319-4534
DOI: 10.1016/j.sjopt.2011.02.002